In order to compare new wheat cultivars and lines, an experiment was implemented in the form of split plots (randomized complete blocks) with three replications for two years at the Chahartakhte research station, Shahrekord, located in the agricultural and natural resources research center of Chaharmahal and Bakhtiari Province. The main treatments included three levels of irrigation, corresponding to (FI) 100%, (I80) 80%, and (I65) 65% soil moisture deficiency, while the subplots featured six wheat cultivars (Mihan, Heydari, line CD-94-9, line CD-94-8, Oroom, and Pishgam). The results of analysis of variance showed that the effect of irrigation levels on grain yield, total yield, plant height, harvest index, 1000 grams grain weight, spike length, water use efficiency and water productivity were significant at 1% level. The highest amount of grain yield was obtained from the Mihan cultivar with FI treatment with 7.85 tons/ha, which were placed in the same statistical group with the yield of two cultivars, Heydari and Pishgam. The lowest amount of grain yield was obtained from the Heidari cultivar treatment with the I65 irrigation level with 2.81 tons per hectare. The highest water use efficiency and water productivity were 2.06 and 1.83 kg/m3, respectively, obtained from Mihan cultivar treatment in FI irrigation management. The lowest water use efficiency and water productivity were 1.13 and 1.01 kg/m3, respectively, obtained from Heydari cultivar and I65 treatments.